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Raratm1Rev
Targeted Allele Detail
Nomenclature
Symbol: Raratm1Rev
Name: retinoic acid receptor, alpha; targeted mutation 1, Ronald M Evans
MGI ID: MGI:2158687
Synonyms: Rara1 null, RARalpha1 -
Gene: Rara  Location: Chr11:98818644-98865768 bp, + strand  Genetic Position: Chr11, 62.76 cM, cytoband D-E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:3997
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA DNA fragment containing a portion of the coding sequence downstream of the sixth codon was replaced with a neomycin selection cassette. Northern blot and RT-PCR analysis on skin, muscle and liver samples of homozygous mice demonstrated that no detectable transcript is produced from this allele. (J:3997)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 10 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rara Mutation:  77 strains or lines available
References
Original:  J:3997 Li E, et al., Normal development and growth of mice carrying a targeted disruption of the alpha 1 retinoic acid receptor gene. Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1590-4
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory