Hnf4a^tm1Dnl
Targeted Allele Detail

Summary

• Symbol: Hnf4a^tm1Dnl
• Name: hepatic nuclear factor 4, alpha; targeted mutation 1, James E Darnell
• MGI ID: MGI:2158682
• Synonyms: HNF-4 -
• Gene: Hnf4a Location: Chr2:163348731-163414827 bp, + strand Genetic Position: Chr2, 84.32 cM
• Alliance: Hnf4a^tm1Dnl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:21129
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A genomic fragment containing exons 2 and 3 was replaced with a neomycin selection cassette. (J:21129)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hnf4a Mutation: 27 strains or lines available

References

• Original: J:21129 Chen WS, et al., Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes Dev. 1994 Oct 15;8(20):2466-77
• All: 6 reference(s)