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Targeted Allele Detail
Symbol: Blmtm2Brd
Name: Bloom syndrome, RecQ helicase-like; targeted mutation 2, Allan Bradley
MGI ID: MGI:2158669
Synonyms: Blmm2
Gene: Blm  Location: Chr7:80454993-80535119 bp, - strand  Genetic Position: Chr7, 45.65 cM
Germline Transmission:  Earliest citation of germline transmission: J:66261
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsThree copies of a targeting vector inserted into the gene. The authors predict that an aberrant transcript containing 4 copies of exon 3 is made. However, western blot analysis on protein extracts of testes demonstrated that no detectable protein was produced from this allele. (J:66261)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Blm Mutation:  29 strains or lines available
Other alleles of this gene serve as models for Bloom Syndrome. This allele results in embryonic lethality and could not be studied in this context.

Original:  J:66261 Luo G, et al., Cancer predisposition caused by elevated mitotic recombination in bloom mice. Nat Genet. 2000 Dec;26(4):424-9
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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