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Pkiatm1Idz
Targeted Allele Detail
Summary
Symbol: Pkiatm1Idz
Name: protein kinase inhibitor, alpha; targeted mutation 1, Rejean L Idzerda
MGI ID: MGI:2158639
Synonyms: PKIalpha -
Gene: Pkia  Location: Chr3:7431729-7510426 bp, + strand  Genetic Position: Chr3, 1.96 cM
Alliance: Pkiatm1Idz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:61791
Parent Cell Line:  REK3 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic fragment containing exon 1 was replaced with a neomycin selection cassette. This exon encodes most of the protein. Northern blot analysis confirmed that no detectable transcript is produced from this allele. (J:61791)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pkia Mutation:  6 strains or lines available
References
Original:  J:61791 Gangolli EA, et al., Deficient gene expression in protein kinase inhibitor alpha Null mutant mice. Mol Cell Biol. 2000 May;20(10):3442-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory