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Targeted Allele Detail
Symbol: Bdkrb1tm1Bdr
Name: bradykinin receptor, beta 1; targeted mutation 1, Michael Bader
MGI ID: MGI:2158501
Synonyms: B1 -, B1-KO, B1R-, B1 receptor-deficient
Gene: Bdkrb1  Location: Chr12:105604091-105605511 bp, + strand  Genetic Position: Chr12, 55.81 cM, cytoband F1
Germline Transmission:  Earliest citation of germline transmission: J:63271
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin selection cassette was inserted into the coding region of the gene. RNAse protection assays on RNA derived from various tissues of homozygous mice demonstrated that no detectable transcript was produced from this allele. A specific agonist of the encoded receptor failed to elicit responses in isolated ileum from homozygous mice, confirming that no functional protein is produced from this allele. (J:63271)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bdkrb1 Mutation:  12 strains or lines available
Original:  J:63271 Pesquero JB, et al., Hypoalgesia and altered inflammatory responses in mice lacking kinin B1 receptors [see comments]. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8140-5
All:  28 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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