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Bmpr1btm1Kml
Targeted Allele Detail
Nomenclature
Symbol: Bmpr1btm1Kml
Name: bone morphogenetic protein receptor, type 1B; targeted mutation 1, Karen M Lyons
MGI ID: MGI:2158497
Synonyms: Bmpr1b-, Bmpr1bn, BmprIB -
Gene: Bmpr1b  Location: Chr3:141837136-142169425 bp, - strand  Genetic Position: Chr3, 66.11 cM
Skeletal abnormalities in Bmpr1btm1Kml/Bmpr1btm1Kml, Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr Tg(Col2a1-cre)1Bhr/?, and Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr Bmpr1btm1Kml/Bmpr1btm1Kml Tg(Col2a1-cre)1Bhr/? mice

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:59282
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic fragment containing the first coding exon was replaced with a neomycin selection cassette. RT-PCR analysis on total embryo RNA from homozygous embryos demonstrated that an aberrant transcript is produced from this allele, but the authors predict that no functional protein can be produced. (J:59282)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 46 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bmpr1b Mutation:  2 strains or lines available
References
Original:  J:59282 Yi SE, et al., The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb. Development. 2000 Feb;127(3):621-30
All:  27 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory