Akt2^tm1Mbb
Targeted Allele Detail

Summary

• Symbol: Akt2^tm1Mbb
• Name: Akt serine/threonine kinase 2; targeted mutation 1, Morris J Birnbaum
• MGI ID: MGI:2158455
• Synonyms: Akt2 T
• Gene: Akt2 Location: Chr7:27290977-27340251 bp, + strand Genetic Position: Chr7, 15.94 cM, cytoband B1
• Alliance: Akt2^tm1Mbb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71491
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked PGK-neomycin resistance cassette was inserted into intron 5, and loxP sites were inserted flanking exons 4 and 5. (J:71491)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Akt2 Mutation: 54 strains or lines available

References

• Original: J:71491 Cho H, et al., Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science. 2001 Jun 1;292(5522):1728-31
• All: 8 reference(s)