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Bcl3tm1Sbn
Targeted Allele Detail
Nomenclature
Symbol: Bcl3tm1Sbn
Name: B cell leukemia/lymphoma 3; targeted mutation 1, Ulrich Siebenlist
MGI ID: MGI:2158443
Synonyms: Bcl3-
Gene: Bcl3  Location: Chr7:19808462-19822770 bp, - strand  Genetic Position: Chr7, 9.95 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:39747
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic fragment containing the coding sequences for most of the ankyrin repeat-encoding exons was replaced with a neomycin selection cassette. Northern blot analysis on RNA derived from various tissues of homozygous mice demonstrated that no detectable transcript was produced from this allele. (J:39747)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bcl3 Mutation:  42 strains or lines available
References
Original:  J:39747 Franzoso G, et al., Critical roles for the Bcl-3 oncoprotein in T cell-mediated immunity, splenic microarchitecture, and germinal center reactions. Immunity. 1997 Apr;6(4):479-90
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/07/2017
MGI 6.11
The Jackson Laboratory