Bcl6^tm1Rdf
Targeted Allele Detail

Summary

• Symbol: Bcl6^tm1Rdf
• Name: B cell leukemia/lymphoma 6; targeted mutation 1, Riccardo Dalla-Favera
• MGI ID: MGI:2158437
• Synonyms: BCL-6^delta
• Gene: Bcl6 Location: Chr16:23783802-23807602 bp, - strand Genetic Position: Chr16, 15.26 cM
• Alliance: Bcl6^tm1Rdf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40769
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exons 8 and 9 was replaced with a neomycin selection cassette. The authors state that this allele encodes a truncated protein lacking the DNA-binding and nuclear localization domains (data not shown). (J:40769)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl6 Mutation: 55 strains or lines available

References

• Original: J:40769 Ye BH, et al., The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat Genet. 1997 Jun;16(2):161-70
• All: 6 reference(s)