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Targeted Allele Detail
Symbol: Bcl2l2tm1Sco
Name: BCL2-like 2; targeted mutation 1, Suzanne Cory
MGI ID: MGI:2158430
Synonyms: bcl-w-, bcl-wdelta
Gene: Bcl2l2  Location: Chr14:54883377-54888234 bp, + strand  Genetic Position: Chr14, 27.98 cM
Germline Transmission:  Earliest citation of germline transmission: J:50338
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment containing two-thirds of the coding region was replaced with a neomycin selection cassette flanked by loxP sites. The neomycin cassette was removed via Cre mediated recombination in the final allele. Northern blot analysis on testis RNA derived from homozygous mice demonstrated that no detectable transcript is produced from this allele, and western blot analysis confirmed that no detectable protein was present in brain, testis or pancreas of homozygous mice. (J:50338)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bcl2l2 Mutation:  8 strains or lines available
Original:  J:50338 Print CG, et al., Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12424-31
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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