About   Help   FAQ
Targeted Allele Detail
Symbol: Apoetm3(APOE*4)Mae
Name: apolipoprotein E; targeted mutation 3, Nobuyo Maeda
MGI ID: MGI:2158398
Synonyms: 4, apoe4, Apoe4, APOE*4, apoE4-KI, apoE4 TR, Apoetm3(APOE)Mae, E4, TgH/ApoE4/N8, TRE4
Gene: Apoe  Location: Chr7:19430034-19433113 bp, - strand  Genetic Position: Chr7, 9.94 cM
Germline Transmission:  Earliest citation of germline transmission: J:74417
Parent Cell Line:  BK4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion
Apoetm3(APOE*4)Mae expresses 1 gene
Mutation detailsA DNA fragment containing exons 2-4 of the human APOE gene (the APOE4 isoform) replaced an equivalent portion of the mouse Apoe gene. Western blot analysis on plasma derived from homozygous mice demonstrated that the human protein was expressed from this allele and the endogenous mouse protein was not detectable. (J:74417)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Apoe Mutation:  139 strains or lines available
Original:  J:74417 Knouff C, et al., Apo E structure determines VLDL clearance and atherosclerosis risk in mice. J Clin Invest. 1999 Jun;103(11):1579-86
All:  149 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.21
The Jackson Laboratory