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Apoetm3(APOE*4)Mae
Targeted Allele Detail
Nomenclature
Symbol: Apoetm3(APOE*4)Mae
Name: apolipoprotein E; targeted mutation 3, Nobuyo Maeda
MGI ID: MGI:2158398
Synonyms: 4, apoe4, Apoe4, APOE*4, apoE4-KI, apoE4 TR, Apoetm3(APOE)Mae, E4, TgH/ApoE4/N8, TRE4
Gene: Apoe  Location: Chr7:19696109-19699166 bp, - strand  Genetic Position: Chr7, 9.94 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:74417
Parent Cell Line:  BK4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion
 
Apoetm3(APOE*4)Mae expresses 1 gene
 
Mutation detailsA DNA fragment containing exons 2-4 of the human APOE gene (the APOE4 isoform) replaced an equivalent portion of the mouse Apoe gene. Western blot analysis on plasma derived from homozygous mice demonstrated that the human protein was expressed from this allele and the endogenous mouse protein was not detectable. (J:74417)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Apoe Mutation:  57 strains or lines available
References
Original:  J:74417 Knouff C, et al., Apo E structure determines VLDL clearance and atherosclerosis risk in mice. J Clin Invest. 1999 Jun;103(11):1579-86
All:  61 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/17/2015
MGI 5.21
The Jackson Laboratory