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Apoetm1(APOE*2)Mae
Targeted Allele Detail
Nomenclature
Symbol: Apoetm1(APOE*2)Mae
Name: apolipoprotein E; targeted mutation 1, Nobuyo Maeda
MGI ID: MGI:2158396
Synonyms: 2, Apoe2, APOE*2, APOE2 TR, Apoetm1(APOE)Mae, E2, TgH/ApoE2/N8
Gene: Apoe  Location: Chr7:19696109-19699166 bp, - strand  Genetic Position: Chr7, 9.94 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:48565
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion
 
Apoetm1(APOE*2)Mae expresses 1 gene
 
Mutation detailsA DNA fragment containing exons 2-4 of the human APOE gene (the APOE2 isoform) replaced an equivalent portion of the mouse Apoe gene. Western blot analysis on plasma derived from homozygous mice demonstrated that the human protein was expressed from this allele and the endogenous mouse protein was not detectable. (J:48565)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apoe Mutation:  53 strains or lines available
References
Original:  J:48565 Sullivan PM, et al., Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2. J Clin Invest. 1998 Jul 1;102(1):130-5
All:  39 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory