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Targeted Allele Detail
Symbol: Apoetm1(APOE*2)Mae
Name: apolipoprotein E; targeted mutation 1, Nobuyo Maeda
MGI ID: MGI:2158396
Synonyms: 2, Apoe2, APOE*2, APOE2 TR, Apoetm1(APOE)Mae, E2, TgH/ApoE2/N8, TRE2
Gene: Apoe  Location: Chr7:19696109-19699188 bp, - strand  Genetic Position: Chr7, 9.94 cM
Germline Transmission:  Earliest citation of germline transmission: J:48565
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion
Apoetm1(APOE*2)Mae expresses 1 gene
Mutation detailsA DNA fragment containing exons 2-4 of the human APOE gene (the APOE2 isoform) replaced an equivalent portion of the mouse Apoe gene. Western blot analysis on plasma derived from homozygous mice demonstrated that the human protein was expressed from this allele and the endogenous mouse protein was not detectable. (J:48565)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Apoe Mutation:  81 strains or lines available
Original:  J:48565 Sullivan PM, et al., Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2. J Clin Invest. 1998 Jul 1;102(1):130-5
All:  45 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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