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Slc12a1tm1Tkh
Targeted Allele Detail
Nomenclature
Symbol: Slc12a1tm1Tkh
Name: solute carrier family 12, member 1; targeted mutation 1, Nobuyuki Takahashi
MGI ID: MGI:2158359
Synonyms: NKCC2-, Slc12a1tm1Unc
Gene: Slc12a1  Location: Chr2:125152600-125230002 bp, + strand  Genetic Position: Chr2, 61.23 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:62224
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 12 kb genomic fragment containing the promoter and exons 1-3 was replaced with a neomycin selection cassette. Western blot analysis on kidney proteins derived from homozygous mice demonstrated that no protein is produced from this allele. (J:62224)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Slc12a1 Mutation:  1 strain or line available
References
Original:  J:62224 Takahashi N, et al., Uncompensated polyuria in a mouse model of Bartter's syndrome. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5434-9
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/14/2019
MGI 6.14
The Jackson Laboratory