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Targeted Allele Detail
Symbol: Plntm1Egk
Name: phospholamban; targeted mutation 1, Evangelia G Kranias
MGI ID: MGI:2158357
Synonyms: PLB-, PLB-KO, PLN-
Gene: Pln  Location: Chr10:53337686-53345999 bp, + strand  Genetic Position: Chr10, 27.11 cM, cytoband B3
Germline Transmission:  Earliest citation of germline transmission: J:39745
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 1.8 kb genomic fragment containing the coding sequences of the gene was replaced with a neomycin selection gene lacking a polyadenylation signal. The authors state that no detectable cardiac muscle transcript or protein was produced from this allele (data not shown). (J:39745)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 7 strains available      Cell Lines: 0 lines available
Carrying any Pln Mutation:  10 strains or lines available
Original:  J:39745 Luo W, et al., Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation. Circ Res. 1994 Sep;75(3):401-9
All:  67 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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