Pln^tm1Egk
Targeted Allele Detail

Summary

• Symbol: Pln^tm1Egk
• Name: phospholamban; targeted mutation 1, Evangelia G Kranias
• MGI ID: MGI:2158357
• Synonyms: PLB^-, PLB-KO, PLN^-
• Gene: Pln Location: Chr10:53213782-53222095 bp, + strand Genetic Position: Chr10, 27.11 cM, cytoband B3
• Alliance: Pln^tm1Egk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39745
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.8 kb genomic fragment containing the coding sequences of the gene was replaced with a neomycin selection gene lacking a polyadenylation signal. The authors state that no detectable cardiac muscle transcript or protein was produced from this allele (data not shown). (J:39745)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 7 strains available Cell Lines: 0 lines available
• Carrying any Pln Mutation: 16 strains or lines available

References

• Original: J:39745 Luo W, et al., Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation. Circ Res. 1994 Sep;75(3):401-9
• All: 79 reference(s)