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Targeted Allele Detail
Symbol: Mecp2tm1.1Jae
Name: methyl CpG binding protein 2; targeted mutation 1.1, Rudolf Jaenisch
MGI ID: MGI:2158354
Synonyms: Mecp1lox, Mecp2tm1-1Jae
Gene: Mecp2  Location: ChrX:74026592-74085690 bp, - strand  Genetic Position: ChrX, 37.63 cM
Germline Transmission:  Earliest citation of germline transmission: J:67909
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThis allele is a derivative of Mecp2tm1Jae in which exon 3 is deleted by Cre mediated recombination in a germline transmissible event. Mice carrying Mecp2tm1Jae were mated to transgenic mice carrying a cre transgene under the control of a nestin promoter. This promoter was active in the male and female germline as well as the brain, and progeny of the cross were screened for deletion of exon 3. (J:67909)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Mecp2 Mutation:  22 strains or lines available
Original:  J:67909 Chen RZ, et al., Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. Nat Genet. 2001 Mar;27(3):327-31
All:  79 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory