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Targeted Allele Detail
Symbol: Mecp2tm1.1Jae
Name: methyl CpG binding protein 2; targeted mutation 1.1, Rudolf Jaenisch
MGI ID: MGI:2158354
Synonyms: Mecp1lox, Mecp2tm1-1Jae
Gene: Mecp2  Location: ChrX:74026592-74085690 bp, - strand  Genetic Position: ChrX, 37.63 cM
Germline Transmission:  Earliest citation of germline transmission: J:67909
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThis allele is a derivative of Mecp2tm1Jae in which exon 3 is deleted by Cre mediated recombination in a germline transmissible event. Mice carrying Mecp2tm1Jae were mated to transgenic mice carrying a cre transgene under the control of a nestin promoter. This promoter was active in the male and female germline as well as the brain, and progeny of the cross were screened for deletion of exon 3. (J:67909)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Mecp2 Mutation:  29 strains or lines available
Original:  J:67909 Chen RZ, et al., Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. Nat Genet. 2001 Mar;27(3):327-31
All:  67 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory