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Mecp2tm1Jae
Targeted Allele Detail
Nomenclature
Symbol: Mecp2tm1Jae
Name: methyl CpG binding protein 2; targeted mutation 1, Rudolf Jaenisch
MGI ID: MGI:2158353
Synonyms: Mecp2lox
Gene: Mecp2  Location: ChrX:74026592-74085690 bp, - strand  Genetic Position: ChrX, 37.63 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:67909
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsLoxP sites were inserted flanking exon 3 as follows: A single loxP site was inserted 5' to exon 3 and a loxP-flanked hygromycin and thymidine kinase selection cassette was inserted 3' to exon 3. The selection cassette was removed in ES cells by Cre-mediated recombination prior to the production of chimeric mice, leaving a single loxP site in place of the selection cassette. (J:67909)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Mecp2 Mutation:  19 strains or lines available
References
Original:  J:67909 Chen RZ, et al., Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. Nat Genet. 2001 Mar;27(3):327-31
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory