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Baxtm1Dlo
Targeted Allele Detail
Nomenclature
Symbol: Baxtm1Dlo
Name: BCL2-associated X protein; targeted mutation 1, Dennis Y Loh
MGI ID: MGI:2158306
Synonyms: bax-
Gene: Bax  Location: Chr7:45461697-45466898 bp, - strand  Genetic Position: Chr7, 29.32 cM, cytoband B5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:39573
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A 5.6 kb genomic fragment containing exons 2-6 was replaced with a neomycin selection cassette. (J:39573)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bax Mutation:  22 strains or lines available
Notes
This allele is described in the materials and methods of the above listed reference as a gift from D. Y. Loh, but it was not independently published.
References
Original:  J:39573 Shindler KS, et al., Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice. J Neurosci. 1997 May 1;17(9):3112-9
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory