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Targeted Allele Detail
Symbol: Bcl2tm1Tsu
Name: B cell leukemia/lymphoma 2; targeted mutation 1, Yoshihide Tsujimoto
MGI ID: MGI:2158305
Synonyms: bcl-2 -
Gene: Bcl2  Location: Chr1:106538178-106714274 bp, - strand  Genetic Position: Chr1, 49.76 cM
Germline Transmission:  Earliest citation of germline transmission: J:22391
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced most of the coding sequences of exon 2. Western blot analysis of spleen and thymus lysates derived from homozygous mice demonstrated that no detectable protein is produced from this allele. (J:22391)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bcl2 Mutation:  37 strains or lines available
Original:  J:22391 Kamada S, et al., bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine. Cancer Res. 1995 Jan 15;55(2):354-9
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory