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Targeted Allele Detail
Symbol: H2-Aatm1Blt
Name: histocompatibility 2, class II antigen A, alpha; targeted mutation 1, Horst Bluethmann
MGI ID: MGI:2157977
Synonyms: Aa0, Aalpha-, MHC class II-
Gene: H2-Aa  Location: Chr17:34282744-34287823 bp, - strand  Genetic Position: Chr17, 17.98 cM
Germline Transmission:  Earliest citation of germline transmission: J:16372
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsInsertion of a PGK-neomycin resistance cassette into exon 2, which encodes the alpha-1 domain of the A-alpha chain, disrupted the gene. Cytofluorometric analyses of lymphocytes from thymus and lymph nodes did not detect expression of the A-alphaA-beta heterodimer in homozygous mutant mice. (J:16372)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any H2-Aa Mutation:  14 strains or lines available
Original:  J:16372 Kontgen F, et al., Targeted disruption of the MHC class II Aa gene in C57BL/6 mice. Int Immunol. 1993 Aug;5(8):957-64
All:  38 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory