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Arrb2tm1Rjl
Targeted Allele Detail
Nomenclature
Symbol: Arrb2tm1Rjl
Name: arrestin, beta 2; targeted mutation 1, Robert J Lefkowitz
MGI ID: MGI:2157960
Synonyms: Arr3-, Arrb2-, betaarr2-, betarr2-KO
Gene: Arrb2  Location: Chr11:70432635-70440828 bp, + strand  Genetic Position: Chr11, 42.99 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:59162
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsPGK-neomycin cassette replaced the entire second exon. This resulted in the deletion of amino acids 9-19. The absence of protein was demonstrated by immunoblotting of extracts from brainstem, periaqueductal gray tissue, spleen, lung, and skin. (J:59162)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 15 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Arrb2 Mutation:  6 strains or lines available
References
Original:  J:59162 Bohn LM, et al., Enhanced morphine analgesia in mice lacking beta-arrestin 2. Science. 1999 Dec 24;286(5449):2495-8
All:  124 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory