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Itgamtm1Bll
Targeted Allele Detail
Nomenclature
Symbol: Itgamtm1Bll
Name: integrin alpha M; targeted mutation 1, Christie M Ballantyne
MGI ID: MGI:2157556
Synonyms: CD11b-, CR3-, CR3/MAC-1-, deltaalphaM, Mac-1-
Gene: Itgam  Location: Chr7:128062640-128118491 bp, + strand  Genetic Position: Chr7, 69.93 cM, cytoband F4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:39092
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 0.7kb genomic fragment containing exon 4 was replaced with a neomycin selection cassette. RT-PCR and RNAse protection assays demonstrated that a mutant transcript is produced from this allele that splices exon 3 to exon 5, which results in a frameshift mutation. Immunohistochemistry analysis revealed that no encoded protein was detectable in spleen sections from homozygous mice. (J:39092)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itgam Mutation:  30 strains or lines available
References
Original:  J:39092 Lu H, et al., LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient mice. J Clin Invest. 1997 Mar 15;99(6):1340-50
All:  49 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory