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Transgenic Allele Detail
Symbol: Ift88Tg737Rpw
Name: intraflagellar transport 88; transgene insertion 737, Richard P Woychik
MGI ID: MGI:2157527
Synonyms: Ift88orpk, orpk, Tg737orpk, Tg737orpk, Tg737(o)(rpk), Tg737Rpw, TgN737Rpw, TgN(Imorpk)737Rpw
Gene: Ift88  Location: Chr14:57424064-57517936 bp, + strand  Genetic Position: Chr14, 30.1 cM
Strain of Origin:  FVB/N
Transgene Type:    Transgenic
Mutation:    Insertion
Mutation detailsA random transgene insertional event resulted in the deletion of approximately 2.7kb at the transgene insertion site in an intron of the gene, but no exons were deleted. Northern blot analysis revealed that expression of a 3.2 and 7.0kb transcript was abolished in RNA from all tissues derived from homozygous mice. The allele is hypomorphic. (J:18508)
Inheritance:    Not Specified
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 22 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ift88 Mutation:  4 strains or lines available
Original:  J:18508 Moyer JH, et al., Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice. Science. 1994 May 27;264(5163):1329-33
All:  49 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory