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Twist1Pde
Chemically induced Allele Detail
Nomenclature
Symbol: Twist1Pde
Name: twist basic helix-loop-helix transcription factor 1; polydactyly EMS
MGI ID: MGI:2157489
Synonyms: Pde, TwistJ
Gene: Twist1  Location: Chr12:33957671-33959829 bp, + strand  Genetic Position: Chr12, 14.81 cM, cytoband B-C1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60747
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Chemically induced (other) (Not Applicable)
Mutation:    Undefined
 
Mutation detailsA complementation test confirmed that Pde is an allele of Twist. Sequencing the full-length cDNA and several hundred basepairs of genomic DNA upstream of the coding region failed to reveal a mutation, suggesting that the lesion may be in a regulatory element of the gene. (J:69450)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Twist1 Mutation:  7 strains or lines available
References
Original:  J:60747 Munroe RJ, et al., Mouse mutants from chemically mutagenized embryonic stem cells. Nat Genet. 2000 Mar;24(3):318-21
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/10/2018
MGI 6.12
The Jackson Laboratory