About   Help   FAQ
Aldh2tm1Kaw
Targeted Allele Detail
Nomenclature
Symbol: Aldh2tm1Kaw
Name: aldehyde dehydrogenase 2, mitochondrial; targeted mutation 1, Toshihiro Kawamoto
MGI ID: MGI:2157245
Synonyms: ALDH2-, mtALDH-
Gene: Aldh2  Location: Chr5:121566027-121593824 bp, - strand  Genetic Position: Chr5, 61.86 cM, cytoband F-G1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:63498
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA termination codon and a neomycin selection cassette was inserted into exon 3. Western blot analysis on liver mitochondrial fractions derived from homozygous mice confirmed that the protein was not expressed at detectable levels. (J:63498)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Aldh2 Mutation:  16 strains or lines available
References
Original:  J:63498 Kitagawa K, et al., Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse. FEBS Lett. 2000 Jul 7;476(3):306-11
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory