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Apohtm1Krl
Targeted Allele Detail
Nomenclature
Symbol: Apohtm1Krl
Name: apolipoprotein H; targeted mutation 1, Steven A Krilis
MGI ID: MGI:2157224
Synonyms: beta2GPI -
Gene: Apoh  Location: Chr11:108343354-108414396 bp, + strand  Genetic Position: Chr11, 71.8 cM, cytoband D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:68990
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 4.7kb genomic fragment containing part of exon 2 and exon 3 was replaced with a neomycin selection cassette. Northern blot analysis revealed that no encoded transcript was detectable in liver RNA derived from homozygous mice, and western blot analysis on plasma derived from homozygous mice demonstrated that no encoded protein was detectable. (J:68990)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apoh Mutation:  7 strains or lines available
References
Original:  J:68990 Sheng Y, et al., Impaired thrombin generation in beta 2-glycoprotein I null mice. J Biol Chem. 2001 Apr 27;276(17):13817-21
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory