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Targeted Allele Detail
Symbol: Lyntm1Ard
Name: LYN proto-oncogene, Src family tyrosine kinase; targeted mutation 1, Ashley R Dunn
MGI ID: MGI:2157129
Synonyms: Lyn-
Gene: Lyn  Location: Chr4:3678115-3813122 bp, + strand  Genetic Position: Chr4, 2.05 cM
Germline Transmission:  Earliest citation of germline transmission: J:29356
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neomycin resistance cassette replaced ~11.5kb of sequence, including the promoter and associated regulatory sequences. RT-PCR analysis of liver did not detect wild-type transcript in homozygous mutant mice. Immunoprecipitation and kinase assays of liver and spleen did not detect LYN autokinase activity in homozygous mutant mice. (J:29356)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lyn Mutation:  32 strains or lines available
Original:  J:29356 Hibbs ML, et al., Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease. Cell. 1995 Oct 20;83(2):301-11
All:  33 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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