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Rasgrf1tm1Kln
Targeted Allele Detail
Nomenclature
Symbol: Rasgrf1tm1Kln
Name: RAS protein-specific guanine nucleotide-releasing factor 1; targeted mutation 1, Rudiger Klein
MGI ID: MGI:2157015
Synonyms: Ras-GRF -, Ras-GRF1-KO
Gene: Rasgrf1  Location: Chr9:89909908-90026977 bp, + strand  Genetic Position: Chr9, 47.31 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:73879
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic fragment containing exons 3-5 was replaced with a neomycin selection cassette. This region encodes the exchange-factor catalytic domain. Western blot analysis on brain extracts of homozygous mice indicated that no detectable protein was produced from this allele. (J:73879)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rasgrf1 Mutation:  29 strains or lines available
References
Original:  J:73879 Brambilla R, et al., A role for the Ras signalling pathway in synaptic transmission and long-term memory. Nature. 1997 Nov 20;390(6657):281-6
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory