Pax8^tm1Pgr
Targeted Allele Detail

Summary

• Symbol: Pax8^tm1Pgr
• Name: paired box 8; targeted mutation 1, Peter Gruss
• MGI ID: MGI:2156985
• Synonyms: Pax8-
• Gene: Pax8 Location: Chr2:24310572-24365611 bp, - strand Genetic Position: Chr2, 16.43 cM, cytoband B
• Alliance: Pax8^tm1Pgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47310
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The vector containing a neo cassette was targeted to exon 2. A thymidine kinase gene was inserted at the 3' end of the construct. This leads to complete inactivation as the putative splicing from exon 1 to exon 3 renders the codons out of frame, terminating after 11 heterologous amino acids. (J:47310)

Disease models

Expression

In Mice Carrying this Mutation:	45 assay results
In Structures Affected by this Mutation:	34 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pax8 Mutation: 32 strains or lines available

References

• Original: J:47310 Mansouri A, et al., Follicular cells of the thyroid gland require Pax8 gene function. Nat Genet. 1998 May;19(1):87-90
• All: 33 reference(s)