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Targeted Allele Detail
Symbol: Itgb1tm1Mll
Name: integrin beta 1 (fibronectin receptor beta); targeted mutation 1, Ulrich Muller
MGI ID: MGI:2156945
Synonyms: B1-loxP1, beta1-flox, Itb1fl, Itgbeta1flox, Itgbeta1fx
Gene: Itgb1  Location: Chr8:128685654-128733200 bp, + strand  Genetic Position: Chr8, 76.09 cM, cytoband E2
Germline Transmission:  Earliest citation of germline transmission: J:71122
Parent Cell Line:  JM-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsLoxP sites were inserted flanking the first coding exon as follows: One loxP site was inserted 5' to the exon and a loxP-flanked neomycin and thymidine kinase selection cassette was inserted 3' to the exon. The neomycin and thymidine kinase selection cassette was removed via Cre-mediated recombination in ES cells prior to creation of chimeric mice, leaving one loxP site in place of the cassette. (J:71122)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 39 assay results
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Itgb1 Mutation:  14 strains or lines available
Original:  J:71122 Graus-Porta D, et al., Beta1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex. Neuron. 2001 Aug 16;31(3):367-79
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory