Pax6^10Neu
Chemically induced Allele Detail

Summary

• Symbol: Pax6^10Neu
• Name: paired box 6; 10, Neuherberg
• MGI ID: MGI:2156820
• Synonyms: ENU-6037
• Gene: Pax6 Location: Chr2:105499245-105527709 bp, + strand Genetic Position: Chr2, 55.31 cM
• Alliance: Pax6^10Neu page

Mutation origin

• Strain of Origin: (102 x C3H)F1

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation was identified as C to T substitution in exon 6, nucleotide position 469. The resulting protein has a Gln to Stop substitution at amino acid position 103. The mutation resides in the paired box region of the protein. The paired box domain, linker region, homeodomain, and P/S/T domains are all deleted in the resulting protein. (J:73625)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pax6 Mutation: 90 strains or lines available

Notes

Genbank Accession ID: AJ307468

References

• Original: J:73625 Favor J, et al., Molecular Characterization of Pax6(2Neu) Through Pax6(10Neu). An extension of the pax6 allelic series and the identification of two possible hypomorph alleles in the mouse mus musculus. Genetics. 2001 Dec;159(4):1689-700
• All: 1 reference(s)