Pax6^2Neu
Chemically induced Allele Detail

Summary

• Symbol: Pax6^2Neu
• Name: paired box 6; 2, Neuherberg
• MGI ID: MGI:2156812
• Synonyms: ENU-5011
• Gene: Pax6 Location: Chr2:105499245-105527709 bp, + strand Genetic Position: Chr2, 55.31 cM
• Alliance: Pax6^2Neu page

Mutation origin

• Strain of Origin: (102 x C3H)F1

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation was identified as a T to C substitution at nucleotide position 2 of the intron 9 donor splice site. The isolated cDNA was 87 bp longer than wild-type due to the destruction of the endogenous splice site and the use of a cryptic splice site. The resulting protein was wild-type up to codon 269 of exon 9 and included 23 amino acids and a stop codon from the inclusive inton. The mutation resides in the homeobox region of the protein. (J:73625)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pax6 Mutation: 90 strains or lines available

Notes

Genbank Accession ID: Y19193

References

• Original: J:63651 Favor J, et al., Saturation mutagenesis for dominant eye morphological defects in the mouse Mus musculus. Mamm Genome. 2000 Jul;11(7):520-5
• All: 2 reference(s)