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Pax63Neu
Chemically induced Allele Detail
Nomenclature
Symbol: Pax63Neu
Name: paired box 6; 3, Neuherberg
MGI ID: MGI:2156742
Synonyms: Enu-65, ENU-65
Gene: Pax6  Location: Chr2:105668900-105697364 bp, + strand  Genetic Position: Chr2, 55.31 cM
Mutation
origin
Strain of Origin:  (102 x C3H)F1
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Insertion
 
Mutation detailsThe mutation was identified as the insertion of single nucleotide (A) In exon 7 following Nucleotide 598. The frameshift results in normal protein through codon 145 of exon 7 followed by 12 aberrant amino acids and a premature stop codon. The linker region, homeodomain, and P/S/T domains are all deleted in the resulting protein. (J:73625)
Phenotypes
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Disease models
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Expression
In Mice Carrying this Mutation: 1 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pax6 Mutation:  38 strains or lines available
Notes
Genbank Accession ID: Y19195

References
Original:  J:21950 Favor J, A comparison of the dominant cataract and recessive specific-locus mutation rates induced by treatment of male mice with ethylnitrosourea. Mutat Res. 1983 Aug;110(2):367-82
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/17/2015
MGI 5.21
The Jackson Laboratory