Amh^tm4Bhr
Targeted Allele Detail

Summary

• Symbol: Amh^tm4Bhr
• Name: anti-Mullerian hormone; targeted mutation 4, Richard R Behringer
• MGI ID: MGI:2156551
• Synonyms: R3-neo
• Gene: Amh Location: Chr10:80641077-80643482 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Amh^tm4Bhr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58474
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Point mutations were introduced in the promoter region corresponding to the SF-1 (Nr5a1) binding site and the Sox9 binding site. A loxP-flanked neomycin selection cassette was placed within intron 1. (J:58474)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Amh Mutation: 23 strains or lines available

References

• Original: J:58474 Arango NA, et al., Targeted mutagenesis of the endogenous mouse Mis gene promoter: in vivo definition of genetic pathways of vertebrate sexual development. Cell. 1999 Nov 12;99(4):409-19
• All: 1 reference(s)