Cadfar^C57BL/6NCrl
QTL Variant Detail

Summary

• QTL variant: Cadfar^C57BL/6NCrl
• Name: cadmium-induced forelimb autopod reduction defect; C57BL/6NCrl
• MGI ID: MGI:2156461
• QTL: Cadfar Location: unknown Genetic Position: Chr6, cM position of peak correlated region/allele: 78.49 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6NCrl

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to cadmium-induced forlimb malformations compared to SWV/Fnn. (J:60691)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:60691

The heavy metal cadmium (Cd) is a potent teratogen in mice and induces forelimb defects in the C57BL/6 strain while no limb defects are observed in identically treated SWV strain. To identify potential fetal loci influencing differential sensitivity to cadmium-induced forelimb malformations, a series of QTL analysis was performed among 198 [C57BL/6 x (C57BL/6 x SWV)]F1 backcross mice utilizing a linkage map of 149 microsatellite markers. A penetrance scan of the binary trait detected one locus with a lodscore of 2.67 (P = 0.00045) located on the distal end of mouse Chromosome 6 near D6Mit390. The binary data were converted to a semi-quantitative trait based on the severity of the defect and analyzed by the parametric and non-parametric scan functions of MAPMAKER/QTL. Both analysis identified the same QTL on Chromosome 6, just centromeric of D6Mit390. The peak lod score was 2.32 when analyzed with the non-parametric approach and 3.08 when analyzed with the parametric scan. This locus has been designated as Cadfar.

References

• Original: J:60691 Hovland DN, et al., Identification of a murine locus conveying susceptibility to cadmium-induced forelimb malformations. Genomics. 2000 Jan 15;63(2):193-201
• All: 1 reference(s)