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CadfarC57BL/6NCrl
QTL Variant Detail
Nomenclature
QTL variant: CadfarC57BL/6NCrl
Name: cadmium-induced forelimb autopod reduction defect; C57BL/6NCrl
MGI ID: MGI:2156461
QTL: Cadfar  Location: unknown  Genetic Position: Chr6, cM position of peak correlated region/allele: 78.49 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C57BL/6NCrl
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers susceptibility to cadmium-induced forlimb malformations compared to SWV/Fnn. (J:60691)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:60691

The heavy metal cadmium (Cd) is a potent teratogen in mice and induces forelimb defects in the C57BL/6 strain while no limb defects are observed in identically treated SWV strain. To identify potential fetal loci influencing differential sensitivity to cadmium-induced forelimb malformations, a series of QTL analysis was performed among 198 [C57BL/6 x (C57BL/6 x SWV)]F1 backcross mice utilizing a linkage map of 149 microsatellite markers. A penetrance scan of the binary trait detected one locus with a lodscore of 2.67 (P = 0.00045) located on the distal end of mouse Chromosome 6 near D6Mit390. The binary data were converted to a semi-quantitative trait based on the severity of the defect and analyzed by the parametric and non-parametric scan functions of MAPMAKER/QTL. Both analysis identified the same QTL on Chromosome 6, just centromeric of D6Mit390. The peak lod score was 2.32 when analyzed with the non-parametric approach and 3.08 when analyzed with the parametric scan. This locus has been designated as Cadfar.

References
Original:  J:60691 Hovland DN, et al., Identification of a murine locus conveying susceptibility to cadmium-induced forelimb malformations. Genomics. 2000 Jan 15;63(2):193-201
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/12/2021
MGI 6.17
The Jackson Laboratory