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Gene trapped Allele Detail
Symbol: Lrp6Gt(Ex187)Byg
Name: low density lipoprotein receptor-related protein 6; gene trap Ex187, BayGenomics
MGI ID: MGI:2156191
Synonyms: lrp6-, Lrp6betageo, Lrp6Gt(pGT1.8TM)187Wcs, Lrp6lacZ
Gene: Lrp6  Location: Chr6:134423439-134543876 bp, - strand  Genetic Position: Chr6, 65.37 cM
Lrp6Cd/Lrp6Gt(Ex187)Byg mice reveal a range of phenotypes

Show the 1 phenotype image(s) involving this allele.

Mutant Cell Line:  Ex187
Germline Transmission:  Earliest citation of germline transmission: J:64989
Parent Cell Line:  CGR8 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT1.8TM
Mutation detailsInsertion of a gene trap vector into the gene that joined the first 321 amino acids of the encoded protein in frame to a beta-galactosidase-neomycin resistance reporter gene. Northern blot analysis demonstrated that no normal transcript was encoded by this allele. (J:64989)
Inheritance:    Recessive
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 55 assay results
In Structures Affected by this Mutation: 22 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lrp6 Mutation:  58 strains or lines available
Original:  J:37528 Skarnes WC, et al., Capturing genes encoding membrane and secreted proteins important for mouse development. Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6592-6
All:  43 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.19
The Jackson Laboratory