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Targeted Allele Detail
Symbol: Adam3tm1Pmkf
Name: a disintegrin and metallopeptidase domain 3 (cyritestin); targeted mutation 1, Paul Primakoff
MGI ID: MGI:2156167
Synonyms: cyritestin -, Cyrn -
Gene: Adam3  Location: Chr8:24677225-24725852 bp, - strand  Genetic Position: Chr8, 13.09 cM, cytoband A2
Germline Transmission:  Earliest citation of germline transmission: J:69282
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment containing exon 14 was replaced with a neomycin selection cassette. Western blots on sperm extracts confirmed the absence of the full length protein in homozygous mice. (J:69282)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adam3 Mutation:  25 strains or lines available
Original:  J:69282 Nishimura H, et al., Analysis of loss of adhesive function in sperm lacking cyritestin or fertilin beta. Dev Biol. 2001 May 1;233(1):204-13
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory