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Targeted Allele Detail
Symbol: Aicdatm1Hon
Name: activation-induced cytidine deaminase; targeted mutation 1, Tasuku Honjo
MGI ID: MGI:2156156
Synonyms: AID-
Gene: Aicda  Location: Chr6:122530768-122541139 bp, + strand  Genetic Position: Chr6, 57.65 cM, cytoband F2
Germline Transmission:  Earliest citation of germline transmission: J:73659
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced exon 2 and part of exon 3, which encodes the cytidine deaminase motif. RT-PCR studies of cultured spleen cells did not detect wild-type transcripts in homozygous mutant mice. (J:73659)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 7 strains available      Cell Lines: 0 lines available
Carrying any Aicda Mutation:  49 strains or lines available
Original:  J:73659 Muramatsu M, et al., Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell. 2000 Sep 1;102(5):553-63
All:  196 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory