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Ptentm1Hwu
Targeted Allele Detail
Nomenclature
Symbol: Ptentm1Hwu
Name: phosphatase and tensin homolog; targeted mutation 1, Hong Wu
MGI ID: MGI:2156086
Synonyms: Ptenex5lox, PTENF, Ptenfl, Ptenflox, Ptenfx, Ptenlox, Ptenloxp
Gene: Pten  Location: Chr19:32757497-32826160 bp, + strand  Genetic Position: Chr19, 28.14 cM
Ovary tumors in Pik3catm1.1Waph/Pik3catm1.1Waph Ptentm1Hwu/Ptentm1Hwu mice

Show the 1 image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75117
Parent Cell Line:  LW1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Floxed/Frt)
Mutation:    Insertion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Pten Mutation:  36 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Chronic intestinal pseudoobstruction J:155110.

Phenotypic Similarity to Human Syndrome: Granulosa cell tumor of the testis (GCTT) J:149060.

Phenotypic Similarity to Human Syndrome: Granulosa cell tumor (GCT) J:142150.

Phenotypic Similarity to Human Syndrome: Glioblastoma J:172585.

Phenotypic Similarity to Human Syndrome: B cell lymphoma J:166155.

Phenotypic Similarity to Human Syndrome: Astrocytoma J:134611

Phenotypic Similarity to Human Syndrome: Thyroid Carcinoma (J:177181)

Phenotypic Similarity to Human Syndrome: Granulosa cell tumor (GCT) J:186144

Phenotypic Similarity to Human Syndrome: Granulosa cell tumor of the testis (GCTT) J:186144

Phenotypic Similarity to Human Syndrome: PTEN Hamartoma Tumor Syndrome (see OMIM:601728 Phosphatase And Tensin Homolog; PTEN) J:199362

References
Original:  J:75117 Lesche R, et al., Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene. Genesis. 2002 Feb;32(2):148-9
All:  225 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory