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Clgntm1Osb
Targeted Allele Detail
Nomenclature
Symbol: Clgntm1Osb
Name: calmegin; targeted mutation 1, Research Institute for Microbial Diseases, Osaka University
MGI ID: MGI:2156041
Synonyms: calmegin-, Clgntm1Oka
Gene: Clgn  Location: Chr8:83389867-83428552 bp, + strand  Genetic Position: Chr8, 39.97 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:40831
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsInsertion of a neomycin resistance cassette into the second exon disrupted the start codon. Northern blot analysis of testis did not detect transcript in homozygous mutant mice. Immunoblot analysis of testis did not detect protein in homozygous mutant mice. (J:40831)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Clgn Mutation:  6 strains or lines available
References
Original:  J:40831 Ikawa M, et al., The putative chaperone calmegin is required for sperm fertility. Nature. 1997 Jun 5;387(6633):607-11
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory