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Adora2atm1Jfc
Targeted Allele Detail
Nomenclature
Symbol: Adora2atm1Jfc
Name: adenosine A2a receptor; targeted mutation 1, Jiang-Fan Chen
MGI ID: MGI:2155985
Synonyms: A2A, A2AAR-, A2A KO, A2aR-, A2AR KO, Adora2atm1Chren, gKO
Gene: Adora2a  Location: Chr10:75316877-75334784 bp, + strand  Genetic Position: Chr10, 38.52 cM, cytoband B5.3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:73594
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsPart of exon 2 and intron 2 was replaced by a neomycin selection cassette. The absence of functional protein was demonstrated in homozygous mice by in situ binding assays and neurochemical tests. (J:73594)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adora2a Mutation:  20 strains or lines available
References
Original:  J:73594 Chen JF, et al., A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice. J Neurosci. 1999 Nov 1;19(21):9192-200
All:  100 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory