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Acetm3Unc
Targeted Allele Detail
Nomenclature
Symbol: Acetm3Unc
Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; targeted mutation 3, University of North Carolina
MGI ID: MGI:2155951
Synonyms: Tg(Acedup)2Unc, TgH(Acedup)2Unc
Gene: Ace  Location: Chr11:105858774-105880790 bp, + strand  Genetic Position: Chr11, 68.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:42519
Parent Cell Line:  BK4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsA gap-repair type targeting vector was used to induce a gene duplication. Two tandem copies of the gene were present in the final allele. Protein activity measurments correlated with gene dosage in serum and lung tissue. (J:42519)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ace Mutation:  36 strains or lines available
References
Original:  J:42519 Krege JH, et al., Angiotensin-converting enzyme gene mutations, blood pressures, and cardiovascular homeostasis. Hypertension. 1997 Jan;29(1 Pt 2):150-7
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory