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QTL Variant Detail
QTL variant: Cms1C57BL/6J
Name: resistance to Coccidioides immitis 1; C57BL/6J
MGI ID: MGI:2155783
QTL: Cms1  Location: Chr4:62509169-62519918 bp  Genetic Position: Chr4, Syntenic
Strain of Specimen:  C57BL/6J
Allele Type:    QTL
Mutation:    Undefined
    This allele confers susceptibility to Coccidioides immitis infection compared to DBA/2J.
Inheritance:    Not Specified
Cms1C57BL/6J/Cms1DBA/2J heterozygotes are resistant. It is not known whether intermediate susceptibility is due to a third allele of Cms1 or to modifying genes. Males are more susceptible than females, although Cms1 is not X-linked (J:7871).

Mapping and Phenotype information for this QTL, its variants and associated markers


DBA/2J mice are more resistant to Coccidioides immitis infection then are C57BL/6J mice allowing for the genetic mapping of genes that determine resistance. The BXD RI line was informative to map genes to mouse Chromosomes 4 and 6. One gene was designated as Cms1 and showed a significant association with mouse Chromosome 4 marker Alad the other gene Cms2 was associated with Tnfrsf1a on mouse Chromosome 6. Moreover (DBA/2J x C57BL/6J) F1 x C57BL/6J backcross progeny that carried the DBA/2J allele at either Tnfrsf1a or Alad exhibited a higher resistant phenotype then mice that carried the C57BL/6J allele.

Original:  J:55132 Fierer J, et al., Genes influencing resistance to Coccidioides immitis and the interleukin-10 response map to chromosomes 4 and 6 in mice. Infect Immun. 1999 Jun;67(6):2916-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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