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Psen1tm1Psgh
Targeted Allele Detail
Nomenclature
Symbol: Psen1tm1Psgh
Name: presenilin 1; targeted mutation 1, Peter St George-Hyslop
MGI ID: MGI:2155771
Synonyms: PS1-
Gene: Psen1  Location: Chr12:83688563-83735199 bp, + strand  Genetic Position: Chr12, 38.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66016
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Psen1 Mutation:  22 strains or lines available
References
Original:  J:66016 Chen F, et al., Carboxyl-terminal fragments of alzheimer beta -amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells. J Biol Chem. 2000 Nov 24;275(47):36794-802
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory