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QTL Variant Detail
QTL variant: Bpq3C57BL/6J
Name: blood pressure QTL 3; C57BL/6J
MGI ID: MGI:2155724
QTL: Bpq3  Location: Chr4:59402240-59402381 bp  Genetic Position: Chr4, cM position of peak correlated region/allele: 32.54 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Strain of Specimen:  C57BL/6J
Allele Type:    QTL
Mutation:    Undefined
    This allele confers susceptibility to salt-induced hypertension compared to A/J. (J:66987)
Inheritance:    Not Specified
View phenotypes and curated references for all genotypes (concatenated display).

Mapping and Phenotype information for this QTL, its variants and associated markers


C57BL/6J are sensitive to salt induced hypertension whereas A/J are non-salt-sensitive allowing for a genome wide scan for loci contributing to hypertension. 250 male mice from reciprocal backcrosses between (C57BL/6J x A/J)F1 x C57BL/6J were informativein mapping 6 Blood pressure QTLs to 5 mouse chromosomes. Bpq3 had a main effect and mapped with markers on mouse Chromosome 4. Bpq3 mapped with D4Mit164 with an F value of 56 and a P value of 1.3 x 10e-12. A suggested candidate for Bpq3 was Npr2.

Original:  J:66987 Sugiyama F, et al., Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci. Genomics. 2001 Jan 1;71(1):70-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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