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Pbx1tm1Mlc
Targeted Allele Detail
Nomenclature
Symbol: Pbx1tm1Mlc
Name: pre B cell leukemia homeobox 1; targeted mutation 1, Michael L Cleary
MGI ID: MGI:2155612
Synonyms: Pbx1-
Gene: Pbx1  Location: Chr1:168119364-168432270 bp, - strand  Genetic Position: Chr1, 75.95 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:71996
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsInsertion of a PGK-neomycin resistance cassette into exon 3, upstream of sequences encoding the homeodomain, disrupted the gene. Western blot analysis using a monoclonal antibody specific for the most abundunt isoform of the protein did not detect any protein product in homozygous mutant E16 embryos. Immunohistochemical analysis using this same antibody did not detect nuclear or cytoplasmic expression in limb buds of E11.5 homozygous mutant embryos. (J:71996)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 67 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pbx1 Mutation:  19 strains or lines available
References
Original:  J:71996 Selleri L, et al., Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation. Development. 2001 Sep;128(18):3543-57
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory