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Chemically induced Allele Detail
Symbol: Myo7a3336SB
Name: myosin VIIA; shaker 3336SB
MGI ID: MGI:2155420
Synonyms: Myo7ash1-3R, sh13336SB, sh1OR-3336SB
Gene: Myo7a  Location: Chr7:98051060-98119524 bp, - strand  Genetic Position: Chr7, 53.57 cM
Strain of Origin:  BALB/cRl
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsA T-to-A transversion mutation is predicted to result in a cysteine to stop codon change at position 2182 in the encoded protein. This mutation is predicted to lie within the tail domain of the protein. Northern blot analysis indicated that mRNA expression, size, and stability were unaffected. Immunoblot analysis showed that approximately 13% of the normal level of the protein was expressed. (J:49926)
Inheritance:    Recessive
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Myo7a Mutation:  33 strains or lines available
Original:  J:73419 Rinchik EM, et al., Reverse genetics in the mouse and its application to the study of deafness. Ann N Y Acad Sci. 1991;630:80-92
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
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