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Chemically induced Allele Detail
Symbol: Myo7a26SB
Name: myosin VIIA; shaker 26SB
MGI ID: MGI:2155417
Synonyms: 26SB, Myo7ash1-1R, sh126SB, sh1OR-26SB
Gene: Myo7a  Location: Chr7:98051060-98119524 bp, - strand  Genetic Position: Chr7, 53.57 cM
Strain of Origin:  BALB/cRl
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsA T-to-A transversion mutation is predicted to result in a phenylalanine to isoleucine change at position 1800 in the encoded protein. This mutation is predicted to lie within the tail domain of the protein. Northern blot analysis indicated that mRNA expression, size, and stability were unaffected. Immunoblot analysis showed that 46% of the normal level of the protein was expressed in testis and 18% of the normal level in kidney. (J:49926)
Inheritance:    Recessive
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Myo7a Mutation:  33 strains or lines available
Original:  J:10283 Rinchik EM, et al., A strategy for fine-structure functional analysis of a 6- to 11-centimorgan region of mouse chromosome 7 by high-efficiency mutagenesis. Proc Natl Acad Sci U S A. 1990 Feb;87(3):896-900
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory