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QTL Variant Detail
QTL variant: Bomb1SL/Kh
Name: bone marrow pre-B 1; SL/Kh
MGI ID: MGI:2155342
QTL: Bomb1  Location: Chr3:128133243-128133417 bp  Genetic Position: Chr3, cM position of peak correlated region/allele: 56.89 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Strain of Specimen:  SL/KhStmRbrc
Allele Type:    QTL
Mutation:    Undefined
    This allele confers lymphoma susceptibility compared to NSF/N. (J:55364)
Inheritance:    Other (see notes)
View phenotypes and curated references for all genotypes (concatenated display).
Bomb1 exhibits an additive mode of inheritance. This allele decreases pre-B cell percentages.

Mapping and Phenotype information for this QTL, its variants and associated markers


SL/Kh inbred mice exhibit a high incidence of pre-B lymphomas and an abnormal transient expression of bone marrow pre-B-1 cells, whereas NFS/N mice have a low incidence of spontaneous lymphoma and a low number of bone marrow pre-B-1 cells. F2 and backcross populations of mice derived from crosses betweeb SL/Kh and NFS/N mice were informative in mapping a QTL to mouse Chromosome 3 with a peak LOD (10.7) at marker D3Mit319. A gene within the QTL region that may be a candidate for the Bomb1 phenotype is suggested to be Lef1.

Original:  J:55364 Lu LM, et al., Bone marrow pre-B-1 (Bomb1): a quantitative trait locus inducing bone marrow pre-B-cell expansion in lymphoma-prone SL/Kh mice. Cancer Res. 1999 Jun 1;59(11):2593-5
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.21
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