About   Help   FAQ
Bfq1C57BL/10SnJ
QTL Variant Detail
Summary
QTL variant: Bfq1C57BL/10SnJ
Name: body fat QTL 1; C57BL/10SnJ
MGI ID: MGI:2155178
QTL: Bfq1  Location: unknown  Genetic Position: Chr2, Syntenic
Variant
origin
Strain of Specimen:  C57BL/10SnJ
Variant
description
Allele Type:    QTL
Inheritance:    Not Specified
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:42700

A total of 84 female (NZB/BlNJ x SM/J)F2 mice were analyzed for 126 genetic markers covering all mouse chromosomes except for the Y Chromosome. An obesity quantitative trait locus (QTL) Bfq1, was significantly associated with a region of mouse Chromosome2 bounded distally by D2Mit28 and proximally by D2Mit22. Additionally, mouse congenic strain B10.LP/SnJ which carries a contributed Chromosome 2 segment from inbred LP/J. The segment which covers a range from 2 cM distal of Ada to 2 cM proximal of H13 wasLP/J like for Bfq1. The congenic findings indicate that the obese phenotype designated as Bfq1 segregated with distal mouse Chromosome 2 loci during the construction of congenic strain B10.LP/SnJ. Bfq1 quantitative trait locus (QTL) can be placed on mouse Chromosome 2 between cM postions 69 and 94 close to D2Mit513. In a personal communication from Dr. Aamir Zuberi to MGI it was suggested that the obesity phenotype in B10.LP/SnJ may in fact be unrelated to Bfq1.

References
Original:  J:42700 Lembertas AV, et al., Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q. J Clin Invest. 1997 Sep 1;100(5):1240-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
04/16/2024
MGI 6.23
The Jackson Laboratory