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Targeted Allele Detail
Symbol: Sgcdtm1Kcam
Name: sarcoglycan, delta (dystrophin-associated glycoprotein); targeted mutation 1, Kevin P Campbell
MGI ID: MGI:2154694
Gene: Sgcd  Location: Chr11:46896253-47988969 bp, - strand  Genetic Position: Chr11, 28.09 cM, cytoband B1.2
Germline Transmission:  Earliest citation of germline transmission: J:57107
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced exon 2, which encodes 63 amino acids of the intracellular domain and the entire transmembrane domain. Northern blot analysis revealed that a transcript lacking exon 2 sequences is produced from this allele, but no protein was detected in skeletal muscle membrane enriched preparations of homozygous mice by western blot analysis. (J:57107)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sgcd Mutation:  10 strains or lines available
Original:  J:57107 Coral-Vazquez R, et al., Disruption of the sarcoglycan-sarcospan complex in vascular smooth muscle: a novel mechanism for cardiomyopathy and muscular dystrophy. Cell. 1999 Aug 20;98(4):465-74
All:  8 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.07
The Jackson Laboratory